Actionable Mutations in Stage 4
Transcript
Also in a stage four setting with lung cancer, as we discussed, adenocarcinoma, you definitely want to test for the targetable actionable mutations, EGFR, ALK or ALK, ROS1, BRAF, MET amplification.
Those are important because you can take therapies that are not cytotoxic chemotherapy, nor immune therapy, and use that agent first and usually get a very good response where people gain a lot of weight and feel great. Eventually the tumor does start to progress on that therapy, and then you can employ your additional options of cytotoxic chemotherapy and immune therapy.
Key Takeaways
1. In stage four, you definitely want to test for the targetable actionable mutations.
2. Those are important because you can take therapies that are not cytotoxic chemotherapy or immune therapy, and use that agent first and usually get a very good response where people gain a lot of weight and feel great.
3. Eventually the tumor does start to progress on that therapy, and then you can move to cytotoxic chemotherapy and immune therapy.
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