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We are going from using that general chemotherapy, which is still very much needed and used today. And in those circumstances, we use it when, one, we don’t have a more specific way of attacking the cancer cell, and we also use it mostly when we have taken out a cancer for curative intent with surgery or done curative intent with radiation and chemotherapy. We have found studies that show, if you do subject the body to this poison or the cytotoxic chemotherapy for maybe three months, six months, those people that had it in the curative intent to take it out, if there were any cells remaining that you cannot see, because it takes about 600, 700,000 cancer cells in one place to see it on average CT imaging or the imaging we get to see if you have cancer or not, it takes a lot of those cells to see. We know on studies that even when we thought we got it all that patients obviously recur. Not necessary progression, but recurrence, so the cancer is back. So the studies were done to see if we give chemotherapy, can that cancer be gone forever? Is it more likely that it’s gone forever? And the studies that say yes, that’s when we still usually do what’s called cytotoxic chemotherapy rather than targeted therapy and stuff with a few exceptions.
